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By Michael E. Swartz

Info equipment at the moment on hand and discusses rising recommendations which may have an enormous influence. Highlights post-synthesis processing recommendations.

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73. 74. 75. Weller antigen for epitopes to a resolution of a single amino acid. Proc Natl Acad Sci USA 81:3998–4002, 1984. BA Bunin, MJ Plunkett, JA Ellman. The combinatorial synthesis and chemical and biological evaluation of a 1,4-benzodiazepine library. Proc Natl Acad Sci USA. 91:4708–4712, 1994. SPA Fodor, JL Read, MC Pirrung, L Stryer, AT Lu, D Solas. Light-directed, spatially addressable parallel chemical synthesis. Science 251:767–773, 1991. AV Lemmo, JT Fisher, HM Geysen, DJ Rose. Characterization of an inkjet chemical microdispenser for combinatorial library synthesis.

Results are shown in Fig. 4 where a variety of peptides was monitored in addition to bradykinin, which acted as the internal calibrant. As for all MALDI experiments, it was critical that the right matrix be chosen for the analysis. After initial examinations of different matrices under a stereo microscope followed by the MALDI-TOF experiment, dihydroxy-benzoic acid (DHP) was found to produce the largest crystals and the best results. 0). 6 represents a small amount of undansylated material. 3].

K Burgess, AI Liaw, N Wang. Statistical sampling of resin pools. J Med Chem 37:2985–2987, 1994. P-L Zhao, RB Nachbar, JA Bolognese, KT Chapman. Two new criteria for choosing sample size in combinatorial chemistry. J Med Chem 39:350–352, 1996. KS Lam, SE Salmon, EM Hersh, VJ Hruby, WM Kazmierski, RJ Knapp. A new type of synthetic peptide library for identifying ligand-binding activity. Nature 354:82–84, 1991. RA Houghten, C Pinilla, SE Blondelle, JR Appel, CT Dooley, JH Cuervo. Generation and use of synthetic peptide combinatorial libraries for basic research and drug discovery.

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